Pediatric research · 2026
Cross-sectional associations of clinical predictors and physical activity in pediatric inflammatory bowel disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Martín-Martínez Carlos, Saloni-Gómez Neus, Sánchez-Llorente Paula, Velasco-Rodríguez-Belvís Marta, Muñoz-Codoceo Rosa Ana, Palomino Laura
Аннотация
BACKGROUND: Reduced physical activity (PA) is common in pediatric inflammatory bowel disease (IBD) and may compromise health. This study aimed to examine cross-sectional associations between PA and biomedical, treatment-related, and clinical-psychosocial factors.
METHODS: Single-center cross-sectional study of 45 patients (9-18 years) with Crohn's disease or ulcerative colitis. PA was assessed using Assessment of Physical Activity Levels Questionnaire (APALQ), and health-related quality of life (HRQoL) using IMPACT-III questionnaire. Inflammatory biomarkers, treatment exposure, joint involvement, and disease characteristics were obtained from medical records. Separate multiple linear regression models were constructed for biomarker, treatment, and clinical-demographic domains and adjusted for age and sex.
RESULTS: Lower PA levels were observed in patients with poorer HRQoL, joint involvement, and higher inflammation. In the clinical-demographic model (R² = 0.39, p = 0.009, n = 38), PA was positively associated with HRQoL (β = 0.46, p = 0.004) and negatively associated with joint involvement (β = -0.28, p = 0.041). In the biomarker model (R² = 0.23, p = 0.042, n = 37), higher fecal calprotectin was associated with lower PA (β = -0.41, p = 0.018). Treatment-related variables were not significantly associated with PA (R² = 0.18, p = 0.281, n = 29).
CONCLUSIONS: In pediatric IBD, PA is primarily influenced by quality of life, joint involvement, and inflammatory activity rather than treatment exposure, supporting multidisciplinary strategies addressing psychosocial well-being, joint involvement and disease control.
IMPACT: Provides novel evidence to guide multidisciplinary management strategies in pediatric IBD. Highlights the key role of psychosocial and musculoskeletal factors in shaping activity participation in pediatric IBD. Suggests that interventions to promote physical activity should target quality of life and joint involvement rather than solely biomedical parameters.
METHODS: Single-center cross-sectional study of 45 patients (9-18 years) with Crohn's disease or ulcerative colitis. PA was assessed using Assessment of Physical Activity Levels Questionnaire (APALQ), and health-related quality of life (HRQoL) using IMPACT-III questionnaire. Inflammatory biomarkers, treatment exposure, joint involvement, and disease characteristics were obtained from medical records. Separate multiple linear regression models were constructed for biomarker, treatment, and clinical-demographic domains and adjusted for age and sex.
RESULTS: Lower PA levels were observed in patients with poorer HRQoL, joint involvement, and higher inflammation. In the clinical-demographic model (R² = 0.39, p = 0.009, n = 38), PA was positively associated with HRQoL (β = 0.46, p = 0.004) and negatively associated with joint involvement (β = -0.28, p = 0.041). In the biomarker model (R² = 0.23, p = 0.042, n = 37), higher fecal calprotectin was associated with lower PA (β = -0.41, p = 0.018). Treatment-related variables were not significantly associated with PA (R² = 0.18, p = 0.281, n = 29).
CONCLUSIONS: In pediatric IBD, PA is primarily influenced by quality of life, joint involvement, and inflammatory activity rather than treatment exposure, supporting multidisciplinary strategies addressing psychosocial well-being, joint involvement and disease control.
IMPACT: Provides novel evidence to guide multidisciplinary management strategies in pediatric IBD. Highlights the key role of psychosocial and musculoskeletal factors in shaping activity participation in pediatric IBD. Suggests that interventions to promote physical activity should target quality of life and joint involvement rather than solely biomedical parameters.