European journal of gastroenterology & hepatology · 2026
Medication adherence level and its predictors among inflammatory bowel disease sufferers in a resource-strained healthcare setting.
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Zewdu Woretaw S, Zerihun Tigabu E, Emiru Zemen A, Dagnew Samuel B, Moges Tilaye A, Mussie Desalegn A, Ferede Yared A, Anberbr Sisay S, Alemu Muluken A, Melese Teferi B, Kassaw Abel T
Аннотация
BACKGROUND: Despite novel breakthroughs in the inflammatory bowel disease (IBD) therapeutics armamentarium, nonadherence remains an invisible epidemic. However, its prevalence and determining features were unknown within resource-strained healthcare settings.
METHODS: A hospital-based cross-sectional study was conducted on adults with IBD from December 2023 to July 2024. A standardized questionnaire and medical record review checklist were used to gather data. Multiple ordinal logistic regression analysis was used to adjudicate potential covariates. A variable was deemed statistically significant if its adjusted odds ratio had a P value of below 0.05 at 95% confidence interval.
RESULTS: This study comprised 237 patient cohort (age: mean ± SD, 53.81 ± 6.71 years). Among them, 32.9, 29.96, and 37.14% were low, medium, and high adherents, respectively. Just under half (43.05%) of participants had a high medication regimen complexity score (mean ± SD, 19.46 ± 2.11). Health insurance status, active disease state, medication regimen complexity score, stigma, comorbidity status, adverse drug reactions, and polypharmacy were the potential predictors identified in the final model.
CONCLUSION: Nearly two-thirds of the study's cohort exhibited suboptimal medication adherence, highlighting a significant clinical concern. Policymakers could consider developing key strategies such as integrating pharmacists and Medication Regimen Complexity Index-65 into IBD chronic care, and leveraging a validated, local-language adherence assessment tool offer a powerful approach to optimize treatment adherence among IBD sufferers.
METHODS: A hospital-based cross-sectional study was conducted on adults with IBD from December 2023 to July 2024. A standardized questionnaire and medical record review checklist were used to gather data. Multiple ordinal logistic regression analysis was used to adjudicate potential covariates. A variable was deemed statistically significant if its adjusted odds ratio had a P value of below 0.05 at 95% confidence interval.
RESULTS: This study comprised 237 patient cohort (age: mean ± SD, 53.81 ± 6.71 years). Among them, 32.9, 29.96, and 37.14% were low, medium, and high adherents, respectively. Just under half (43.05%) of participants had a high medication regimen complexity score (mean ± SD, 19.46 ± 2.11). Health insurance status, active disease state, medication regimen complexity score, stigma, comorbidity status, adverse drug reactions, and polypharmacy were the potential predictors identified in the final model.
CONCLUSION: Nearly two-thirds of the study's cohort exhibited suboptimal medication adherence, highlighting a significant clinical concern. Policymakers could consider developing key strategies such as integrating pharmacists and Medication Regimen Complexity Index-65 into IBD chronic care, and leveraging a validated, local-language adherence assessment tool offer a powerful approach to optimize treatment adherence among IBD sufferers.