The Journal of dermatological treatment · 2015
Objective assessment of isotretinoin-associated cheilitis: Isotretinoin Cheilitis Grading Scale.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Ornelas Jennifer, Rosamilia Lorraine, Larsen Larissa, Foolad Negar, Wang Quinlu, Li Chin-Shang, Sivamani Raja K
Аннотация
IMPORTANCE: Isotretinoin remains an effective treatment for severe acne. Despite its effectiveness, it includes many side effects, of which cheilitis is the most common.
OBJECTIVE: To develop an objective grading scale for assessment of isotretinoin-associated cheilitis.
DESIGN: Cross-sectional clinical grading study.
SETTING: UC Davis Dermatology clinic.
PARTICIPANTS: Subjects were older than 18 years old and actively treated with oral isotretinoin.
EXPOSURES: Oral Isotretinoin.
MAIN OUTCOMES AND MEASURES: We developed an Isotretinoin Cheilitis Grading Scale (ICGS) incorporating the following four characteristics: erythema, scale/crust, fissures and inflammation of the commissures. Three board-certified dermatologists independently graded photographs of the subjects.
RESULTS: The Kendall's coefficient of concordance (KCC) for the ICGS was 0.88 (p < 0.0001). The Kendall's coefficient was ≥0.72 (p < 0.0001) for each of the four characteristics included in the grading scale. An image-based measurement for lip roughness statistically significantly correlated with the lip scale/crusting assessment (r = 0.52, p < 0.05).
CONCLUSION AND RELEVANCE: The ICGS is reproducible and relatively simple to use. It can be incorporated as an objective tool to aid in the assessment of isotretinoin associated cheilitis.
OBJECTIVE: To develop an objective grading scale for assessment of isotretinoin-associated cheilitis.
DESIGN: Cross-sectional clinical grading study.
SETTING: UC Davis Dermatology clinic.
PARTICIPANTS: Subjects were older than 18 years old and actively treated with oral isotretinoin.
EXPOSURES: Oral Isotretinoin.
MAIN OUTCOMES AND MEASURES: We developed an Isotretinoin Cheilitis Grading Scale (ICGS) incorporating the following four characteristics: erythema, scale/crust, fissures and inflammation of the commissures. Three board-certified dermatologists independently graded photographs of the subjects.
RESULTS: The Kendall's coefficient of concordance (KCC) for the ICGS was 0.88 (p < 0.0001). The Kendall's coefficient was ≥0.72 (p < 0.0001) for each of the four characteristics included in the grading scale. An image-based measurement for lip roughness statistically significantly correlated with the lip scale/crusting assessment (r = 0.52, p < 0.05).
CONCLUSION AND RELEVANCE: The ICGS is reproducible and relatively simple to use. It can be incorporated as an objective tool to aid in the assessment of isotretinoin associated cheilitis.