BMJ open · 2025
Antibiotic resistance of non-fermenting Gram-negative bacilli in a tertiary hospital in Niger: a prospective cross-sectional study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tapha Ounoussa, Yacouba Abdourahamane, Degbey Cyriaque, Mamoudou Issa Koukou Nafissa, Abass Albana Imrana, Saley Sahada Moussa, Hanki Yahayé, Mounkaila Boutchi, Doutchi Mahamadou, Brah Souleymane, Mamadou Saidou
Аннотация
OBJECTIVE: This study aimed to determine the prevalence and antimicrobial susceptibility profile of non-fermenting Gram-negative bacilli (NFGNB) isolated from clinical samples in a tertiary care hospital in Niger.
DESIGN: Prospective, cross-sectional study.
SETTING: The study was carried out in a tertiary care hospital in Niger.
PARTICIPANTS: All clinical samples received at the bacteriology laboratory during the study period for diagnostic purposes were included.
RESULTS: Out of 548 clinical Gram-negative isolates, 60 strains of NFGNB (10.94%) were isolated. These NFGNB strains were mainly isolated from male patients (62%, n=37) with a mean age of 41.2±27.3 years. NFGNB was more frequent in urine samples (91.7%), followed by pus (6.6%). Among the NFGNB strains isolated, Acinetobacter baumannii was predominant (60%), followed by Pseudomonas aeruginosa (18.3%) and Stenotrophomonas maltophilia (13.33%). 20% (n=12) of NFGNB isolated were multidrug-resistant (MDR), including 13.33% (n=8) carbapenem-resistant A. baumannii and 6.67% (n=4) carbapenem-resistant P. aeruginosa. There is no statistically significant association between MDR-NFGNB and age, sex and origin of patients (p>0.05).
CONCLUSIONS: Our study revealed a relatively high MDR-NFGNB prevalence rate in a Nigerien tertiary care hospital. These findings emphasise the need for vigilant antibiotic stewardship, with appropriate infection prevention and control practices to curb the emergence and spread of MDR-NFGNB infections in hospital settings.
DESIGN: Prospective, cross-sectional study.
SETTING: The study was carried out in a tertiary care hospital in Niger.
PARTICIPANTS: All clinical samples received at the bacteriology laboratory during the study period for diagnostic purposes were included.
RESULTS: Out of 548 clinical Gram-negative isolates, 60 strains of NFGNB (10.94%) were isolated. These NFGNB strains were mainly isolated from male patients (62%, n=37) with a mean age of 41.2±27.3 years. NFGNB was more frequent in urine samples (91.7%), followed by pus (6.6%). Among the NFGNB strains isolated, Acinetobacter baumannii was predominant (60%), followed by Pseudomonas aeruginosa (18.3%) and Stenotrophomonas maltophilia (13.33%). 20% (n=12) of NFGNB isolated were multidrug-resistant (MDR), including 13.33% (n=8) carbapenem-resistant A. baumannii and 6.67% (n=4) carbapenem-resistant P. aeruginosa. There is no statistically significant association between MDR-NFGNB and age, sex and origin of patients (p>0.05).
CONCLUSIONS: Our study revealed a relatively high MDR-NFGNB prevalence rate in a Nigerien tertiary care hospital. These findings emphasise the need for vigilant antibiotic stewardship, with appropriate infection prevention and control practices to curb the emergence and spread of MDR-NFGNB infections in hospital settings.
Предметные рубрики MeSH
HumansMaleCross-Sectional StudiesTertiary Care CentersProspective StudiesFemaleAdultMiddle AgedGram-Negative BacteriaGram-Negative Bacterial InfectionsNigerAnti-Bacterial AgentsMicrobial Sensitivity TestsYoung AdultAgedDrug Resistance, Multiple, BacterialAdolescentPrevalenceDrug Resistance, BacterialAcinetobacter baumanniiPseudomonas aeruginosa