Incidence and distribution of coeliac disease in Campania (Italy): 2011-2013.
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Zingone Fabiana, West Joe, Auricchio Renata, Maria Bevilacqua Rosa, Bile Guido, Borgheresi Patrizia, Erminia Bottiglieri Maria, Caldore Mariano, Capece Giuseppe, Cristina Caria Maria, Crudele Antonio, Cuomo Rosario, Lucia Garofano Maria, Giardullo Nicola, Gerarda Gravina Antonietta, Greco Luigi, Iannotta Patrizia, Kosova Paolo, Lamanda Roberto, Malamisura Basilio, Marmo Riccardo, Napoli Gianfranco, Nardone Gerardo, Pacelli Maria, Pascarella Filomena, Riccio Elisabetta, Riegler Gabriele, Rispo Antonio, Rocco Alba, Romano Marco, Saffiotti Ottavio, Saviano Paola, Sorrentini Italo, Speranza Pietro, Tolone Carlo, Tortora Raffaella, Troncone Riccardo, Ciacci Carolina
Аннотация
METHODS: All coeliac diagnoses made from 2011 to 2013 and registered within the Campania coeliac disease register (CeliacDB) were identified. Incidence rates were analysed by sex, age and province of residence, with a Poisson model fitted to determine incidence rate ratios.
RESULTS: We found 2049 coeliac disease diagnoses registered in the CeliacDB between 2011 and 2013; 1441 of these patients were female (70.4%) and 1059 were aged less than 19 years (51.7%). The overall incidence of coeliac disease in Campania was 11.8 per 100,000 person-years (95% CI 11.3-12.3) during the study period, with marked variation by age [27.4 per 100,000 person-years (95% CI 25.8-29.1) in children under 19 years of age and 7.3 per 100,000 (95% CI 6.8-7.8) in adults] and sex [16.1 per 100,000 person-years in females (95% CI 15.3-16.9) and 7.2 per 100,000 person-years in males (95% CI 6.6-7.8)]. Coeliac disease incidence was roughly similar in Naples, Salerno, Caserta and Avellino, but about half in Benevento. More than 80% of our study population was diagnosed by the combination of positive antitransglutaminase IgA and Marsh 3. More than half of the patients were symptomatic at the time of coeliac disease diagnosis (39.7% had a classical presentation and 21.1% a non-classical one according to the Oslo definition).
CONCLUSIONS: Coeliac disease incidence was roughly similar among Campania provinces, except in Benevento where it was about half, probably due to less awareness of coeliac disease in this area. The incidence of coeliac disease in Campania appears to be lower than that reported by most of the previous literature, suggesting the necessity of new coeliac awareness programmes.