Dermatology (Basel, Switzerland) · 2015
Association between coeliac disease and psoriasis: Italian primary care multicentre study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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De Bastiani Rudi, Gabrielli Maurizio, Lora Liliana, Napoli Luigi, Tosetti Cesare, Pirrotta Enzo, Ubaldi Enzo, Bertolusso Luciano, Zamparella Maria, De Polo Manuela, Nebiacolombo Cristina, Bortot Mario, Mancuso Maurizio, Bacchin Paolo, Marsala Valerio, Pinna Roberto, Tursi Antonio, Benedetto Edoardo, Cuffari Alfredo, Pati Antonino, Di Caro Simona, Perenzin Gastone, Sala Raffaella, Calzavara Pinton Giacomo, Gasbarrini Antonio
Аннотация
BACKGROUND: Studies assessing the association between coeliac disease (CD) and psoriasis show conflicting results.
OBJECTIVE: To assess in the primary care setting the prevalence of CD in patients with psoriasis and the response to a gluten-free diet (GFD) in subjects with psoriasis and CD.
METHODS: We enrolled 218 patients with psoriasis and 264 controls. Coeliac screening was carried out in all subjects (Eurospital, Trieste, Italy). In subjects with a positive serology, the diagnosis of CD was confirmed histologically.
RESULTS: Nine (4.1%) psoriatic patients had positive anti-tissue transglutaminase antibodies compared to only 1 among controls (0.4%, p < 0.05; OR 2.03, 95% CI 1.42-90.11). The diagnosis of CD was confirmed histologically in all 10 subjects. At 6 months GFD was associated with a great improvement of skin lesions in 7 out of 8 patients with psoriasis.
CONCLUSION: Our multicentre primary care study showed an high prevalence of CD in psoriasis and an improvement of skin lesions in CD under GFD.
OBJECTIVE: To assess in the primary care setting the prevalence of CD in patients with psoriasis and the response to a gluten-free diet (GFD) in subjects with psoriasis and CD.
METHODS: We enrolled 218 patients with psoriasis and 264 controls. Coeliac screening was carried out in all subjects (Eurospital, Trieste, Italy). In subjects with a positive serology, the diagnosis of CD was confirmed histologically.
RESULTS: Nine (4.1%) psoriatic patients had positive anti-tissue transglutaminase antibodies compared to only 1 among controls (0.4%, p < 0.05; OR 2.03, 95% CI 1.42-90.11). The diagnosis of CD was confirmed histologically in all 10 subjects. At 6 months GFD was associated with a great improvement of skin lesions in 7 out of 8 patients with psoriasis.
CONCLUSION: Our multicentre primary care study showed an high prevalence of CD in psoriasis and an improvement of skin lesions in CD under GFD.