Journal of neurology · 2018
Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia.
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Jiskoot Lize C, Panman Jessica L, van Asseldonk Lauren, Franzen Sanne, Meeter Lieke H H, Donker Kaat Laura, van der Ende Emma L, Dopper Elise G P, Timman Reinier, van Minkelen Rick, van Swieten John C, van den Berg Esther, Papma Janne M
Аннотация
INTRODUCTION: We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).
METHODS: Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.
RESULTS: MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.
DISCUSSION: Using longitudinal neuropsychological assessment, we detected a mutation-specific pattern of cognitive decline, potentially suggesting prognostic value of neuropsychological trajectories in conversion to symptomatic FTD.
METHODS: Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.
RESULTS: MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.
DISCUSSION: Using longitudinal neuropsychological assessment, we detected a mutation-specific pattern of cognitive decline, potentially suggesting prognostic value of neuropsychological trajectories in conversion to symptomatic FTD.
Предметные рубрики MeSH
AdultCognitive DysfunctionFemaleFollow-Up StudiesFrontotemporal DementiaGenetic Predisposition to DiseaseHeterozygoteHumansIntercellular Signaling Peptides and ProteinsLongitudinal StudiesMaleMiddle AgedMultilevel AnalysisMutationNeuropsychological TestsProdromal SymptomsPrognosisProgranulinsROC CurveRegression Analysistau Proteins