Development of an index to define overall disease severity in IBD.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Siegel Corey A, Whitman Cynthia B, Spiegel Brennan M R, Feagan Brian, Sands Bruce, Loftus Edward V, Panaccione Remo, D'Haens Geert, Bernstein Charles N, Gearry Richard, Ng Siew C, Mantzaris Gerassimos J, Sartor Balfour, Silverberg Mark S, Riddell Robert, Koutroubakis Ioannis E, O'Morain Colm, Lakatos Peter L, McGovern Dermot P B, Halfvarson Jonas, Reinisch Walter, Rogler Gerhard, Kruis Wolfgang, Tysk Curt, Schreiber Stefan, Danese Silvio, Sandborn William, Griffiths Anne, Moum Bjorn, Gasche Christoph, Pallone Francesco, Travis Simon, Panes Julian, Colombel Jean-Frederic, Hanauer Stephen, Peyrin-Biroulet Laurent
Аннотация
METHODS: Using a modified Delphi panel, 14 members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) selected the most important attributes related to IBD. Eighteen IOIBD members then completed a statistical exercise (conjoint analysis) to create a relative ranking of these attributes. Adjusted utilities were developed by creating proportions for each level within an attribute.
RESULTS: For CD, 15.8% of overall disease severity was attributed to the presence of mucosal lesions, 10.9% to history of a fistula, 9.7% to history of abscess and 7.4% to history of intestinal resection. For UC, 18.1% of overall disease severity was attributed to mucosal lesions, followed by 14.0% for impact on daily activities, 11.2% C reactive protein and 10.1% for prior experience with biologics. Overall disease severity indices were created on a 100-point scale by applying each attribute's average importance to the adjusted utilities.
CONCLUSIONS: Based on specialist opinion, overall CD severity was associated more with intestinal damage, in contrast to overall UC disease severity, which was more dependent on symptoms and impact on daily life. Once validated, disease severity indices may provide a useful tool for consistent assessment of overall disease severity in patients with IBD.