The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
Symptomatic and Functional Recovery From Major Depressive Disorder in the Ibadan Study of Ageing.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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История · было → стало
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Ojagbemi Akin, Abiona Taiwo, Luo Zhehui, Gureje Oye
Аннотация
OBJECTIVES: Very little is known about the association between symptomatic and functional recovery from late-life major depressive disorder (MDD) in sub-Saharan Africa. We investigated factors associated with sustained symptomatic remission (SR) from MDD and the 5-year trajectory of post-MDD physical functioning.
DESIGN: 5-year prospective study with three follow-up waves in 2007, 2008, and 2009.
SETTING/PARTICIPANTS: Household multistage probability sample of 2,149 Nigerians who were aged 65 years or older.
MEASUREMENTS: Activities of Daily Living (ADL) and MDD were assessed using the Kadz index and Composite International Diagnostic Interview, respectively. We studied those with current MDD (prevalent in 2003-2004 or incident in 2007), and who achieved SR in subsequent waves compared with a chronic/recurrent course (CR).
RESULTS: Baseline demographic characteristics, health, and lifestyle factors were not associated with SR in logistic regression analyses. In mixed-effect linear regression models adjusting for age, sex, and socioeconomic status, ADL worsened in SR (β = 1.0, 95% CI: 0.2, 1.8), but more so in CR (β = 2.3, 95% CI: 1.6, 3.0). Poorer ADL at follow-up was predicted by age (β = 2.9, 95% CI: 1.8, 4.0) and economic status (β = 1.4, 95% CI: 0.3, 2.4).
CONCLUSIONS: There was a deteriorating course of disability despite symptomatic recovery from late-life MDD in this sample. This finding has implications for policy and guidelines for the management of late-life depression and disability.
DESIGN: 5-year prospective study with three follow-up waves in 2007, 2008, and 2009.
SETTING/PARTICIPANTS: Household multistage probability sample of 2,149 Nigerians who were aged 65 years or older.
MEASUREMENTS: Activities of Daily Living (ADL) and MDD were assessed using the Kadz index and Composite International Diagnostic Interview, respectively. We studied those with current MDD (prevalent in 2003-2004 or incident in 2007), and who achieved SR in subsequent waves compared with a chronic/recurrent course (CR).
RESULTS: Baseline demographic characteristics, health, and lifestyle factors were not associated with SR in logistic regression analyses. In mixed-effect linear regression models adjusting for age, sex, and socioeconomic status, ADL worsened in SR (β = 1.0, 95% CI: 0.2, 1.8), but more so in CR (β = 2.3, 95% CI: 1.6, 3.0). Poorer ADL at follow-up was predicted by age (β = 2.9, 95% CI: 1.8, 4.0) and economic status (β = 1.4, 95% CI: 0.3, 2.4).
CONCLUSIONS: There was a deteriorating course of disability despite symptomatic recovery from late-life MDD in this sample. This finding has implications for policy and guidelines for the management of late-life depression and disability.