Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017
Cortical microstructural changes along the Alzheimer's disease continuum.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Montal Victor, Vilaplana Eduard, Alcolea Daniel, Pegueroles Jordi, Pasternak Ofer, González-Ortiz Sofia, Clarimón Jordi, Carmona-Iragui María, Illán-Gala Ignacio, Morenas-Rodríguez Estrella, Ribosa-Nogué Roser, Sala Isabel, Sánchez-Saudinós María-Belén, García-Sebastian Maite, Villanúa Jorge, Izagirre Andrea, Estanga Ainara, Ecay-Torres Mirian, Iriondo Ane, Clerigue Montserrat, Tainta Mikel, Pozueta Ana, González Andrea, Martínez-Heras Eloy, Llufriu Sara, Blesa Rafael, Sanchez-Juan Pascual, Martínez-Lage Pablo, Lleó Alberto, Fortea Juan
Аннотация
INTRODUCTION: Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD).
METHODS: We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum.
RESULTS: Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages.
DISCUSSION: These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification.
METHODS: We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum.
RESULTS: Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages.
DISCUSSION: These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification.