Pathology, research and practice · 2023
The potential role of miRNAs in the pathogenesis of adrenocortical carcinoma - A focus on signaling pathways interplay.
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Midan Heba M, Helal Gouda Kamel, Abulsoud Ahmed I, Elshaer Shereen Saeid, El-Husseiny Ahmed A, Fathi Doaa, Abdelmaksoud Nourhan M, Abdel Mageed Sherif S, Elballal Mohammed S, Zaki Mohamed Bakr, Abd-Elmawla Mai A, Al-Noshokaty Tohada M, Rizk Nehal I, Elrebehy Mahmoud A, El-Dakroury Walaa A, Hashem Amr H, Doghish Ahmed S
Аннотация
Adrenocortical carcinoma (ACC) is a highly malignant infrequent tumor with a dismal prognosis. microRNAs (miRNAs, miRs) are crucial in post-transcriptional gene expression regulation. Due to their ability to regulate multiple gene networks, miRNAs are central to the hallmarks of cancer, including sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, induction/access to the vasculature, activation of invasion and metastasis, reprogramming of cellular metabolism, and avoidance of immune destruction. ACC represents a singular form of neoplasia associated with aberrations in the expression of evolutionarily conserved short, non-coding RNAs. Recently, the role of miRNAs in ACC has been examined extensively despite the disease's rarity. Hence, the current review is a fast-intensive track elucidating the potential role of miRNAs in the pathogenesis of ACC besides their association with the survival of ACC.