JACC. Basic to translational science · 2021
Association Between Thrombogenicity Indices and Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kang Min Gyu, Koo Bon-Kwon, Tantry Udaya S, Kim Kyehwan, Ahn Jong-Hwa, Park Hyun Woong, Park Jeong Rang, Hwang Seok-Jae, Hwang Jin-Yong, Gurbel Paul A, Samady Habib, Koh Jin-Sin, Jeong Young-Hoon
Аннотация
The association between thrombogenicity and coronary microvascular dysfunction (CMD) has been poorly explored in patients with acute myocardial infarction (AMI). In our real-world clinical practice (N = 116), thrombogenicity was evaluated with thromboelastography and conventional hemostatic measures, and CMD was defined as index of microcirculatory resistance of >40 U using the invasive physiologic test. High platelet-fibrin clot strength (P-FCS) (≥68 mm) significantly increased the risk of postprocedural CMD (odds ratio: 4.35; 95% CI: 1.74-10.89). Patients with both CMD and high P-FCS had a higher rate of ischemic events compared to non-CMD subjects with low P-FCS (odds ratio: 5.58; 95% CI: 1.31-23.68). This study showed a close association between heightened thrombogenicity and CMD and their prognostic implications after reperfusion in acute myocardial infarction patients.