Fever and headache in an intravenous drug user.

Zygomycosis refers to diseases caused by filamentous fungi from the class Zygomycetes. These organisms are ubiquitous in nature and can be found in soil as well as in decaying organic matter such as fruit and bread. Risk factors for zygomycosis include uncontrolled diabetes mellitus, hematologic malignancies, corticosteroid therapy, deferoxamine therapy, intravenous drug use, and malnutrition. Clinical manifestations include rhino-orbital-cerebral, pulmonary, cutaneous, disseminated, gastric, and isolated cerebral disease. Isolated involvement of the central nervous system is rare and is most often associated with intravenous drug use. This case report describes isolated cerebral zygomycosis in an intravenous drug user.