The Journal of infection · 2026
Epidemiology of virologically confirmed RSV, influenza and COVID-19 in adults in England, 2023-2024: Primary Care Observational Study of Acute Respiratory Infection (ObservatARI).
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Ordóñez-Mena José M, Radin Jennifer M, Hoang Uy, Araujo Andre B, Balogh Orsolya, Eltayeb Ahreej, Jamie Gavin, Elson William H, Lu Tianyi, Gu Xinchun, Batool Fatima, Madia Joan, Fan Xuejuan, Byford Rachel, Enesca Ellya, Button Elizabeth, Martin David, Ferreira Filipa, Hoschler Katja, Kele Beatrix, Cogdale Jade, Talts Tiina, Sebastian-Pillai Praveen, Zambon Maria, de Lusignan Simon
Аннотация
OBJECTIVES: To describe the positivity, clinical presentation and predictors of respiratory syncytial virus (RSV) in adult primary care patients compared to influenza and SARS-CoV-2, prior to the introduction of RSV vaccines.
METHODS: We analyzed data from primary care patients aged ≥40 years with an acute respiratory infection. Between 02/10/2023 and 10/04/2024 virology swabs were tested by the UK Health Security Agency for RSV, influenza A and B, and SARS-CoV-2. Percent positivity with 95% confidence intervals (CIs) were estimated. Multivariable logistic regression identified predictors of infection. Clinical presentations were described and compared.
RESULTS: Among 6,161 individuals tested, influenza A had the highest positivity (3.25%, 95% CI: 2.83-3.72), followed by SARS-CoV-2 (2.30%, 95% CI: 1.96-2.71), RSV (2.26%, 95% CI: 1.91-2.66), and influenza B (0.28%, 95% CI: 0.17-0.44). RSV positivity was higher in people aged 60-74 compared to those aged 40-49. RSV cases presented with ILI less often than COVID or influenza A cases.
CONCLUSIONS: During the 2023/24 winter season in England, medically-attended RSV presented a significant disease burden, with a positivity comparable to SARS-CoV-2 and approximately 70% of influenza. Given well-established vaccination programmes for influenza and COVID-19, these findings demonstrate an opportunity to introduce an RSV vaccination programme for adults.
METHODS: We analyzed data from primary care patients aged ≥40 years with an acute respiratory infection. Between 02/10/2023 and 10/04/2024 virology swabs were tested by the UK Health Security Agency for RSV, influenza A and B, and SARS-CoV-2. Percent positivity with 95% confidence intervals (CIs) were estimated. Multivariable logistic regression identified predictors of infection. Clinical presentations were described and compared.
RESULTS: Among 6,161 individuals tested, influenza A had the highest positivity (3.25%, 95% CI: 2.83-3.72), followed by SARS-CoV-2 (2.30%, 95% CI: 1.96-2.71), RSV (2.26%, 95% CI: 1.91-2.66), and influenza B (0.28%, 95% CI: 0.17-0.44). RSV positivity was higher in people aged 60-74 compared to those aged 40-49. RSV cases presented with ILI less often than COVID or influenza A cases.
CONCLUSIONS: During the 2023/24 winter season in England, medically-attended RSV presented a significant disease burden, with a positivity comparable to SARS-CoV-2 and approximately 70% of influenza. Given well-established vaccination programmes for influenza and COVID-19, these findings demonstrate an opportunity to introduce an RSV vaccination programme for adults.