PressureDot® Capsule: A Wireless Ingestible Device for Continuous Intra-Abdominal Pressure Monitoring-Design, Validation, and In Vivo Feasibility.

Continuous intra-abdominal pressure (IAP) monitoring is critical for the early detection and management of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Current standard IAP monitoring is based on intravesical pressure (IVP) monitoring, limited by intermittent measurements, infection risks, and labor-intensive procedures. This study introduces the PressureDot® Capsule, an ingestible, wireless device designed for continuous, non-invasive IAP monitoring by gastrointestinal pressure. The PressureDot® Capsule's performance was evaluated through benchtop and in vivo testing by a porcine model. In benchtop tests, the capsule demonstrated a high correlation with a reference pressure meter (two tests performed, R2 = 0.97 and R2 = 0.94, respectively), confirming its measurement accuracy under controlled conditions. In vivo testing further validated its feasibility, with strong correlations observed between the capsule and true IAP (two tests performed, R2 = 0.81 and R2 = 0.94, respectively). Compared to conventional methods, the PressureDot® Capsule offers advantages, including continuous monitoring, reduced infection risk, labor efficiency, and suitability for outpatient care. Its compact design enhances patient compliance, making it a promising solution for clinical and athletic applications. These findings support PressureDot® Capsule's potential as a transformative tool for real-time IAP monitoring across diverse healthcare settings.Clinical Relevance- The PressureDot® Capsule enables continuous, non-invasive intra-abdominal pressure monitoring, reducing infection risks and labor demands while improving patient outcomes in critical care and outpatient settings.