Cell · 2019
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ponzetta Andrea, Carriero Roberta, Carnevale Silvia, Barbagallo Marialuisa, Molgora Martina, Perucchini Chiara, Magrini Elena, Gianni Francesca, Kunderfranco Paolo, Polentarutti Nadia, Pasqualini Fabio, Di Marco Sabrina, Supino Domenico, Peano Clelia, Cananzi Ferdinando, Colombo Piergiuseppe, Pilotti Silvana, Alomar Suliman Yousef, Bonavita Eduardo, Galdiero Maria Rosaria, Garlanda Cecilia, Mantovani Alberto, Jaillon Sebastien
Аннотация
Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. Neutrophils were essential for the activation of an interferon-γ-dependent pathway of immune resistance, associated with polarization of a subset of CD4- CD8- unconventional αβ T cells (UTCαβ). Bulk and single-cell RNA sequencing (scRNA-seq) analyses unveiled the innate-like features and diversity of UTCαβ associated with neutrophil-dependent anti-sarcoma immunity. In selected human tumors, including undifferentiated pleomorphic sarcoma, CSF3R expression, a neutrophil signature and neutrophil infiltration were associated with a type 1 immune response and better clinical outcome. Thus, neutrophils driving UTCαβ polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.