Gastrointestinal endoscopy · 2012
An endoscopic wireless gastrostimulator (with video).
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Deb Sanchali, Tang Shou-Jiang, Abell Thomas L, Rao Smitha, Huang Wen-Ding, To S D Filip, Lahr Christopher, Chiao Jung-Chih
Аннотация
BACKGROUND: Gastric electric stimulation (GES) at a high-frequency, low-energy setting is an option for treating refractory gastroparesis. The currently available commercial stimulator, the Enterra neurostimulator (Medtronic Inc, Minneapolis, MN), however, requires surgical implantation and is powered by a nonrechargeable battery.
OBJECTIVE: To develop and test a miniature wireless GES device for endoscopic implantation in an experimental model.
DESIGN: In-vivo gastric signals were recorded and measured in a nonsurvival swine model (n = 2; 110-lb animals).
INTERVENTION: An endoscopically placed, wireless GES device was inserted into the stomach through an overtube; the two GES electrodes were endoscopically attached to the gastric mucosa and secured with endoclips to permit stimulation.
MAIN OUTCOME MEASUREMENTS: Stable electrogastrogram measures were observed during GES stimulation.
RESULTS: Electrogastrogram recordings demonstrated that gastric slow waves became more regular and of constant amplitudes when stomach tissues were stimulated, in comparison with no stimulation. The frequency-to-amplitude ratio also changed significantly with stimulation.
LIMITATION: Nonsurvival pig studies.
CONCLUSION: Gastric electric stimulation is feasible by our endoscopically implanted, wireless GES device.
OBJECTIVE: To develop and test a miniature wireless GES device for endoscopic implantation in an experimental model.
DESIGN: In-vivo gastric signals were recorded and measured in a nonsurvival swine model (n = 2; 110-lb animals).
INTERVENTION: An endoscopically placed, wireless GES device was inserted into the stomach through an overtube; the two GES electrodes were endoscopically attached to the gastric mucosa and secured with endoclips to permit stimulation.
MAIN OUTCOME MEASUREMENTS: Stable electrogastrogram measures were observed during GES stimulation.
RESULTS: Electrogastrogram recordings demonstrated that gastric slow waves became more regular and of constant amplitudes when stomach tissues were stimulated, in comparison with no stimulation. The frequency-to-amplitude ratio also changed significantly with stimulation.
LIMITATION: Nonsurvival pig studies.
CONCLUSION: Gastric electric stimulation is feasible by our endoscopically implanted, wireless GES device.