Weak association between retinopathy of prematurity and neurological disorders in childhood.

An attempt was made to elucidate the association between retinopathy of prematurity (ROP) and neurological disorders in infants of very low birth weight. In this retrospective study, 1081 Japanese children weighing less than 1500 g at birth were classified into four subgroups according to birth weight. In each subgroup, the association among cerebral palsy (CP) or mental retardation (MR) and ROP, treated ROP, and cicatricial ROP was analyzed statistically. In the population as a whole, CP and MR were positively associated with ROP. However, in the birth weight subgroup analysis, no significant association was found. We can conclude that there is a weak association between ROP and CP or MR.