[Peculiarities of functional state of endothelium in women with polycystic ovaries].

To reveal factors of elevated risk of development of cardiovascular diseases we examined 59 women with polycystic ovarian syndrome (PCOS). Control group comprised 12 healthy body mass and age matched women. Functional state of endothelium was assessed by endothelium dependent brachial artery dilation (EDV), intima-media thickness (ITM), and endothelin-1 level (ET-1). Carbohydrate metabolism, lipid and hormonal composition of blood were also investigated. Significant differences between groups were revealed in EDV (9.3 +/- 2.95%, 13.8 +/- 2.79%, p=0.001) and ET-1 (1.85 +/- 1.4 fmol/l; 0.4 +/- 0.54 fmol/l). Left/right common carotid artery IMT did not differ significantly between groups (0.52 +/- 1.12/0.55 +/- 0.16 mm; 0.52 +/- 0.05/0.53 +/- 0.05 mm, p > 0.05). 27% of patients with PCOS had metabolic syndrome. Correlation analysis allowed to reveal direct relationship of EDV, IMT, ET-1 with level of fasting immunoreactive insulin (HOMA index). Results of this investigation allow to suggest presence of factors of elevated risk of development of cardiovascular diseases in patients with PCOS.