Archivos de bronconeumologia · 2011
Significance of the presence of lymphocytes in the cytological analysis of transbronchial needle aspiration.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Lucena Carmen M, Agustí Carles, Martínez-Olondris Pilar, Cano-Jiménez Esteban, Marrades Ramón M, Ramírez Josep, Sánchez Marcelo, Arguis Pedro, Xaubet Antoni
Аннотация
AIM: To evaluate the clinical relevance of the presence of lymphocytes in transbronchial needle aspiration (TBNA) samples from pathological mediastinal lymph nodes in patients with suspected lung cancer.
METHODS: Retrospective observational study evaluating the negative predictive value (NPV) of TBNA samples containing lymphocytes but not malignant cells.
RESULTS: A total of 266 TBNA were performed in 252 patients with pathological lymph nodes. One hundred and fifteen TBNA samples had evidence of malignant cells (43%), and 94 (35%) samples were considered as inadequate (absence of adequate cytological material or exclusive presence of bronchial epithelial cells). Out of the 57 TBNA samples remaining (21%), 15 could not be confirmed; in 32, TBNA samples were confirmed with alternative diagnostic techniques and in 10, they were confirmed after clinical and radiological follow-up. The NPV of the 32 samples that were confirmed with alternative diagnostic techniques was 84% decreasing down to 76% when the 10 TBNA samples confirmed after clinical and radiological follow-up were included.
CONCLUSIONS: The presence of lymphocytes in the TBNA sample does not exclude the neoplasic invasion of the specific lymph node analyzed.
METHODS: Retrospective observational study evaluating the negative predictive value (NPV) of TBNA samples containing lymphocytes but not malignant cells.
RESULTS: A total of 266 TBNA were performed in 252 patients with pathological lymph nodes. One hundred and fifteen TBNA samples had evidence of malignant cells (43%), and 94 (35%) samples were considered as inadequate (absence of adequate cytological material or exclusive presence of bronchial epithelial cells). Out of the 57 TBNA samples remaining (21%), 15 could not be confirmed; in 32, TBNA samples were confirmed with alternative diagnostic techniques and in 10, they were confirmed after clinical and radiological follow-up. The NPV of the 32 samples that were confirmed with alternative diagnostic techniques was 84% decreasing down to 76% when the 10 TBNA samples confirmed after clinical and radiological follow-up were included.
CONCLUSIONS: The presence of lymphocytes in the TBNA sample does not exclude the neoplasic invasion of the specific lymph node analyzed.
Предметные рубрики MeSH
AdenocarcinomaAgedAged, 80 and overBiopsy, NeedleBronchiBronchoscopyCarcinoma, Non-Small-Cell LungCarcinoma, Small CellCarcinoma, Squamous CellColonic NeoplasmsFemaleHumansLung NeoplasmsLymph NodesLymphatic MetastasisLymphocyte CountLymphocytesMaleMediastinumMelanomaMiddle AgedPositron-Emission TomographyPredictive Value of TestsRetrospective StudiesSingle-Blind MethodSkin Neoplasms