American journal of ophthalmology · 1998
Pressure-dependent neuroretinal rim loss in normal-pressure glaucoma.
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Jonas J B, Gründler A E, Gonzales-Cortés J
Аннотация
PURPOSE: To evaluate whether, in normal-pressure glaucoma, the level of intraocular pressure is correlated with the degree of glaucomatous optic nerve damage.
METHODS: Color stereo optic disk photographs of 98 eyes with the focal type of normal-pressure glaucoma, 17 eyes with the highly myopic type of normal-pressure glaucoma, and 36 eyes with the age-related atrophic type of primary open-angle glaucoma were morphometrically evaluated.
RESULTS: In all three study groups, neuroretinal rim area declined significantly (P < .05) with increasing maximal intraocular pressure values.
CONCLUSIONS: In different forms of open-angle glaucoma with normal intraocular pressure, eyes with relatively high intraocular pressure have more pronounced optic nerve damage than do eyes with relatively low intraocular pressure. This suggests a barotraumatic aspect in the pathogenesis of optic nerve damage in the normal-pressure glaucomas. It implies that therapeutically, an intraocular pressure in the low-normal range may less likely be associated with glaucoma damage than an intraocular pressure in the upper-normal range would be.
METHODS: Color stereo optic disk photographs of 98 eyes with the focal type of normal-pressure glaucoma, 17 eyes with the highly myopic type of normal-pressure glaucoma, and 36 eyes with the age-related atrophic type of primary open-angle glaucoma were morphometrically evaluated.
RESULTS: In all three study groups, neuroretinal rim area declined significantly (P < .05) with increasing maximal intraocular pressure values.
CONCLUSIONS: In different forms of open-angle glaucoma with normal intraocular pressure, eyes with relatively high intraocular pressure have more pronounced optic nerve damage than do eyes with relatively low intraocular pressure. This suggests a barotraumatic aspect in the pathogenesis of optic nerve damage in the normal-pressure glaucomas. It implies that therapeutically, an intraocular pressure in the low-normal range may less likely be associated with glaucoma damage than an intraocular pressure in the upper-normal range would be.