Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025
Bacteriophage Therapy for Chronic Mastoiditis.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Casazza Julia, Tan Donald, Newcomer Mark, Sakano Hitomi, Isaacson Brandon, Hunter Jacob B
Аннотация
OBJECTIVE: To provide the first description of intratympanic bacteriophage therapy for chronic mastoiditis from multidrug-resistant Pseudomonas aeruginosa in the United States.
PATIENTS: A 47-year-old woman with chronic mastoiditis in the setting of ciliary dysfunction from cystic fibrosis and immunosuppression from lung transplantation.
INTERVENTIONS: Ten concurrent parenteral and intratympanic doses of two custom phages targeting P. aeruginosa followed by IV antibiotic therapy.
MAIN OUTCOME MEASURES: Resolution of infection confirmed by symptomatology, cultures, and imaging.
RESULTS: At 5 months after phage treatment, the patient reported resolution of otorrhea, headaches, and hearing impairment. Subsequent cultures showed no growth.
CONCLUSIONS: Bacteriophages can enhance antibiotic activity in cases of drug-resistant chronic mastoiditis.
PATIENTS: A 47-year-old woman with chronic mastoiditis in the setting of ciliary dysfunction from cystic fibrosis and immunosuppression from lung transplantation.
INTERVENTIONS: Ten concurrent parenteral and intratympanic doses of two custom phages targeting P. aeruginosa followed by IV antibiotic therapy.
MAIN OUTCOME MEASURES: Resolution of infection confirmed by symptomatology, cultures, and imaging.
RESULTS: At 5 months after phage treatment, the patient reported resolution of otorrhea, headaches, and hearing impairment. Subsequent cultures showed no growth.
CONCLUSIONS: Bacteriophages can enhance antibiotic activity in cases of drug-resistant chronic mastoiditis.