Revista da Sociedade Brasileira de Medicina Tropical · 2014
Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice.
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Santarem Ana Angélica Amorim, Greggianin Gabriel Frizon, Debastiani Rafaela Garcia, Ribeiro Jefferson Bruno Pereira, Polli Demerson Andre, Sampaio Raimunda Nonata Ribeiro
Аннотация
INTRODUCTION: The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline.
METHODS: Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria.
RESULTS: The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05).
CONCLUSIONS: There is hope that a viable treatment exists for Leishmania infection.
METHODS: Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria.
RESULTS: The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05).
CONCLUSIONS: There is hope that a viable treatment exists for Leishmania infection.