Science (New York, N.Y.) · 2005

The genome of the African trypanosome Trypanosoma brucei.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен

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Berriman Matthew, Ghedin Elodie, Hertz-Fowler Christiane, Blandin Gaëlle, Renauld Hubert, Bartholomeu Daniella C, Lennard Nicola J, Caler Elisabet, Hamlin Nancy E, Haas Brian, Böhme Ulrike, Hannick Linda, Aslett Martin A, Shallom Joshua, Marcello Lucio, Hou Lihua, Wickstead Bill, Alsmark U Cecilia M, Arrowsmith Claire, Atkin Rebecca J, Barron Andrew J, Bringaud Frederic, Brooks Karen, Carrington Mark, Cherevach Inna, Chillingworth Tracey-Jane, Churcher Carol, Clark Louise N, Corton Craig H, Cronin Ann, Davies Rob M, Doggett Jonathon, Djikeng Appolinaire, Feldblyum Tamara, Field Mark C, Fraser Audrey, Goodhead Ian, Hance Zahra, Harper David, Harris Barbara R, Hauser Heidi, Hostetler Jessica, Ivens Al, Jagels Kay, Johnson David, Johnson Justin, Jones Kristine, Kerhornou Arnaud X, Koo Hean, Larke Natasha, Landfear Scott, Larkin Christopher, Leech Vanessa, Line Alexandra, Lord Angela, Macleod Annette, Mooney Paul J, Moule Sharon, Martin David M A, Morgan Gareth W, Mungall Karen, Norbertczak Halina, Ormond Doug, Pai Grace, Peacock Chris S, Peterson Jeremy, Quail Michael A, Rabbinowitsch Ester, Rajandream Marie-Adele, Reitter Chris, Salzberg Steven L, Sanders Mandy, Schobel Seth, Sharp Sarah, Simmonds Mark, Simpson Anjana J, Tallon Luke, Turner C Michael R, Tait Andrew, Tivey Adrian R, Van Aken Susan, Walker Danielle, Wanless David, Wang Shiliang, White Brian, White Owen, Whitehead Sally, Woodward John, Wortman Jennifer, Adams Mark D, Embley T Martin, Gull Keith, Ullu Elisabetta, Barry J David, Fairlamb Alan H, Opperdoes Fred, Barrell Barclay G, Donelson John E, Hall Neil, Fraser Claire M, Melville Sara E, El-Sayed Najib M

Аннотация

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma brucei. The 26-megabase genome contains 9068 predicted genes, including approximately 900 pseudogenes and approximately 1700 T. brucei-specific genes. Large subtelomeric arrays contain an archive of 806 variant surface glycoprotein (VSG) genes used by the parasite to evade the mammalian immune system. Most VSG genes are pseudogenes, which may be used to generate expressed mosaic genes by ectopic recombination. Comparisons of the cytoskeleton and endocytic trafficking systems with those of humans and other eukaryotic organisms reveal major differences. A comparison of metabolic pathways encoded by the genomes of T. brucei, T. cruzi, and Leishmania major reveals the least overall metabolic capability in T. brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified.

The genome of the African trypanosome Trypanosoma brucei.

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