Maturitas · 2025
Handgrip strength in patients with subclinical hypothyroidism or subclinical hyperthyroidism compared with that in euthyroid individuals: A systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Fernández-Alonso Ana M, García-Alfaro Pascual, Pérez-López Faustino R
Аннотация
OBJECTIVE: This systematic review and meta-analysis assessed handgrip strength in patients with either subclinical hypothyroidism or subclinical hyperthyroidism as compared with euthyroid individuals.
METHODS: We searched in Web of Science, Scopus, and PubMed databases for information about cross-sectional studies comparing subclinical hypothyroid or subclinical hyperthyroid patients and euthyroid control individuals. The quality of included studies was evaluated with the Newcastle-Ottawa Scale. Random-effect meta-analyses were conducted to minimize the effects of uncertainty associated with inter-study variability. Results are reported as mean differences, standardized mean differences, or odds ratios with 95 % confidence intervals. Heterogeneity between studies was assessed using I2 and τ2 statistics.
RESULTS: Seven studies with low or moderate risk of bias were eligible for inclusion in the meta-analysis of patients with either subclinical hypothyroidism or hyperthyroidism compared with euthyroid individuals. The meta-analysis of five studies of patients with subclinical hypothyroidism showed they had lower handgrip strength (standardized mean difference: -0.61, 95 % confidence interval -1.15, -0.07; p = 0.03) and lower thyroxine levels (standardized mean difference: -0.52, 95 % confidence interval -0.87, -0.16; p = 0.004) than euthyroid individuals. They also had a higher body mass index (mean difference: 1.05, 95 % confidence interval: 0.17, 1.93, p = 0.02), higher total cholesterol (standardized mean difference 0.28, 95 % confidence interval 0.09, 0.46, p = 0.003) and lower thyroxine levels (standardized mean difference: -0.52, 95 % confidence interval -0.87, -0.16; p = 0.004), and a higher risk of sarcopenia (odds ratio: 2.12, 95 % confidence interval 1.40, 3.22, p = 0.0004) than euthyroid individuals. The meta-analyses of four studies of patients with subclinical hyperthyroidism did not show differences in measured outcomes compared with euthyroid individuals.
CONCLUSIONS: Patients with subclinical hypothyroidism have lower handgrip strength than euthyroid individuals. There was no significant difference in handgrip strength between patients with subclinical hyperthyroidism and euthyroid individuals. PROSPERO registration: CRD420251004586.
METHODS: We searched in Web of Science, Scopus, and PubMed databases for information about cross-sectional studies comparing subclinical hypothyroid or subclinical hyperthyroid patients and euthyroid control individuals. The quality of included studies was evaluated with the Newcastle-Ottawa Scale. Random-effect meta-analyses were conducted to minimize the effects of uncertainty associated with inter-study variability. Results are reported as mean differences, standardized mean differences, or odds ratios with 95 % confidence intervals. Heterogeneity between studies was assessed using I2 and τ2 statistics.
RESULTS: Seven studies with low or moderate risk of bias were eligible for inclusion in the meta-analysis of patients with either subclinical hypothyroidism or hyperthyroidism compared with euthyroid individuals. The meta-analysis of five studies of patients with subclinical hypothyroidism showed they had lower handgrip strength (standardized mean difference: -0.61, 95 % confidence interval -1.15, -0.07; p = 0.03) and lower thyroxine levels (standardized mean difference: -0.52, 95 % confidence interval -0.87, -0.16; p = 0.004) than euthyroid individuals. They also had a higher body mass index (mean difference: 1.05, 95 % confidence interval: 0.17, 1.93, p = 0.02), higher total cholesterol (standardized mean difference 0.28, 95 % confidence interval 0.09, 0.46, p = 0.003) and lower thyroxine levels (standardized mean difference: -0.52, 95 % confidence interval -0.87, -0.16; p = 0.004), and a higher risk of sarcopenia (odds ratio: 2.12, 95 % confidence interval 1.40, 3.22, p = 0.0004) than euthyroid individuals. The meta-analyses of four studies of patients with subclinical hyperthyroidism did not show differences in measured outcomes compared with euthyroid individuals.
CONCLUSIONS: Patients with subclinical hypothyroidism have lower handgrip strength than euthyroid individuals. There was no significant difference in handgrip strength between patients with subclinical hyperthyroidism and euthyroid individuals. PROSPERO registration: CRD420251004586.