Archives of general psychiatry · 2006
The neural basis of relational memory deficits in schizophrenia.
Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Ongür Dost, Cullen Thomas J, Wolf Daniel H, Rohan Michael, Barreira Paul, Zalesak Martin, Heckers Stephan
Аннотация
CONTEXT: Memory deficits are common in schizophrenia. Recent studies have demonstrated that relational memory is particularly impaired.
OBJECTIVE: To study the neural correlates of relational memory in schizophrenia using functional magnetic resonance imaging.
DESIGN: Cross-sectional case-control study.
SETTING: Academic medical center. Subjects Twenty patients with schizophrenia and 17 control subjects.
MAIN OUTCOME MEASURES: Behavioral performance and brain activity were assessed during the discrimination of previously seen and novel pairs of visual stimuli, which varied in the degree of relational memory load. We performed whole-brain and region-of-interest (hippocampus) analyses.
RESULTS: Schizophrenic subjects displayed normal activation of the presupplementary motor area and ventral prefrontal cortex, but significantly decreased recruitment of the right parietal cortex and anterior cingulate cortex when discriminating novel pairs derived from a sequence of stimuli. Discrimination accuracy was decreased in schizophrenia only when the flexible representation of a sequence was required. This selective deficit was associated with decreased activation of the right parietal cortex and left hippocampus.
CONCLUSIONS: Schizophrenia is characterized by a specific deficit of relational memory, which is associated with impaired function of the parietal cortex and hippocampus. Abnormal relational memory may be at the core of 2 prominent features of schizophrenia, ie, cognitive deficits and psychosis.
OBJECTIVE: To study the neural correlates of relational memory in schizophrenia using functional magnetic resonance imaging.
DESIGN: Cross-sectional case-control study.
SETTING: Academic medical center. Subjects Twenty patients with schizophrenia and 17 control subjects.
MAIN OUTCOME MEASURES: Behavioral performance and brain activity were assessed during the discrimination of previously seen and novel pairs of visual stimuli, which varied in the degree of relational memory load. We performed whole-brain and region-of-interest (hippocampus) analyses.
RESULTS: Schizophrenic subjects displayed normal activation of the presupplementary motor area and ventral prefrontal cortex, but significantly decreased recruitment of the right parietal cortex and anterior cingulate cortex when discriminating novel pairs derived from a sequence of stimuli. Discrimination accuracy was decreased in schizophrenia only when the flexible representation of a sequence was required. This selective deficit was associated with decreased activation of the right parietal cortex and left hippocampus.
CONCLUSIONS: Schizophrenia is characterized by a specific deficit of relational memory, which is associated with impaired function of the parietal cortex and hippocampus. Abnormal relational memory may be at the core of 2 prominent features of schizophrenia, ie, cognitive deficits and psychosis.
Предметные рубрики MeSH
AdultBrain MappingCase-Control StudiesCerebral CortexCognition DisordersCross-Sectional StudiesFemaleFunctional LateralityHippocampusHumansMagnetic Resonance ImagingMaleMemory DisordersModels, NeurologicalNeuropsychological TestsOxygenParietal LobePsychomotor PerformanceSchizophreniaSchizophrenic PsychologyTemporal Lobe