[Bioclinical interest in the assay of leukotrienes in four cases of sensitization to trophallergens].

New cellular tests as flow cytometry and leukotriene release having been set up for allergy diagnosis, we checked the reliability of the LTC4 release test for 4 patients sensitized to wheat flour, oyster and lobster and to anise. Food allergy diagnosis was based on the clinical history, skin tests (pricks and IDR) and specific IgE. After allergen stimulation, LTC4 released was determined by an RIA method using a monoclonal antibody. The allergen extracts used for skin tests and LTC4 release having the same origin, LTC4 release test showed a good correlation with the clinical history whereas specific IgE determinations were less sensitive. Skin tests were negative in the cases.