Journal of the American Academy of Dermatology · 2007
Prevalence of stratified epithelium-specific antinuclear antibodies in 138 patients with lichen planus.
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Parodi Aurora, Cozzani Emanuele, Massone Cesare, Rebora Alfredo, Priano Luigi, Ghigliotti Giovanni, Balbi Paolo, Rongioletti Franco, Micalizzi Claudia, Cestari Rossella, Varaldo Giuseppe, Barabino Gianfranco, Cannata Giuseppe, Drago Francesco, Moreno Vittorio, Schiazza Luciano, Muzio Gianfranco, Scaparro Enrico, Alibrandi Bruno, Bandelloni Roberto, Ciaccio Marina, Desirello Giovanni, Isola Pier Mario, Ottoboni Stefano, Rampini Paolo, Santoro Giuseppe, Sorbara Stefania, Virno Giovanni
Аннотация
BACKGROUND: Antibodies to stratified epithelia characterize chronic ulcerative stomatitis, an entity that very closely resembles erosive lichen planus both clinically and histologically. These antibodies are directed against a 70-kd antigen.
OBJECTIVE: Our aim was to verify whether antibodies to stratified epithelia are present in patients with common lichen planus.
PATIENTS AND METHODS: One hundred thirty-eight patients with various forms of lichen planus were studied. Indirect immunofluorescence was performed on both monkey esophagus and HEp2-2000 cells. Immunoblotting was done with cultured keratinocytes used as the source antigen.
RESULTS: Nineteen patients had antibodies to stratified epithelia (in 9 directed against an antigen of 70 kd). Forty-eight patients had circulating antibodies detected by indirect immunofluorescence on both monkey esophagus and HEp2-2000 cells (in 7 directed against an antigen of 70 kd). Indirect immunofluorescence was positive only on HEp2-2000 cells in 21 patients. Indirect immunofluorescence was negative in 50 patients on both HEp2-2000 cells and monkey esophagus. None of the last 71 patients had antibodies directed to an antigen of 70 kd.
LIMITATIONS: This is a serological study; results from direct immunofluorescence studies would be interesting.
CONCLUSION: Antibodies to stratified epithelia directed to an antigen of 70 kd are not exclusive to chronic ulcerative stomatitis, but are also present in some patients with lichen planus.
OBJECTIVE: Our aim was to verify whether antibodies to stratified epithelia are present in patients with common lichen planus.
PATIENTS AND METHODS: One hundred thirty-eight patients with various forms of lichen planus were studied. Indirect immunofluorescence was performed on both monkey esophagus and HEp2-2000 cells. Immunoblotting was done with cultured keratinocytes used as the source antigen.
RESULTS: Nineteen patients had antibodies to stratified epithelia (in 9 directed against an antigen of 70 kd). Forty-eight patients had circulating antibodies detected by indirect immunofluorescence on both monkey esophagus and HEp2-2000 cells (in 7 directed against an antigen of 70 kd). Indirect immunofluorescence was positive only on HEp2-2000 cells in 21 patients. Indirect immunofluorescence was negative in 50 patients on both HEp2-2000 cells and monkey esophagus. None of the last 71 patients had antibodies directed to an antigen of 70 kd.
LIMITATIONS: This is a serological study; results from direct immunofluorescence studies would be interesting.
CONCLUSION: Antibodies to stratified epithelia directed to an antigen of 70 kd are not exclusive to chronic ulcerative stomatitis, but are also present in some patients with lichen planus.