A comparison between propantheline and imipramine on bladder and salivary gland function.

The effects of propantheline and imipramine on detrusor function and salivary gland secretion were studied in the dog. Both drugs caused a decrease in the rise of intravesical pressure following pelvic nerve stimulation in the anaesthetised dog. Propantheline had a profound effect on the salivary gland, whereas imipramine had very little effect on the volume of saliva produced after electrical stimulation of the chorda tympani. This suggests that the action of imipramine on the bladder is not anticholinergic. The significance for treatment of detrusor dysfunction is discussed.