[The immunomorphological characteristics of chronic recurrent ulcerative stomatitis].

The aim of the present study was to evaluate the immunomorphological characteristics of chronic recurrent ulcerative stomatitis. The patients were divided into 3 groups: 16 patients with mild, 15 patients with moderate, and 9 with severe stomatitis. The cytological smears were stained by Papanicolaou method. We have evaluated indexes of maturation (MI), keratinization (KI), destruction (DI), and inflammation-destruction (IDI). The immunocytochemistry was used to evaluate the local immune reactions. Anti-CD20 (pan-B marker), Anti-CD3 (pan-T marker), CD4 (marker of T helper), CD8 (marker of T cytotoxic lymphocytes) monoclonal antibodies were used (LSAB, DAB). The comparative analysis of cytological indexes in acute and remission phases of chronic recurrent ulcerative stomatitis showed that DI and IDI decreased in remission phase compared with acute phase, but did not return to norm. It seems that inflammation persists in remission phase despite the absence of symptomatic ulcerative lesion. In mild chronic recurrent ulcerative stomatitis the dynamic quantitative changes of immunocompetent cells in acute and remission phases show that the increased number of CD4+ T and CD20+ B lymphocytes has been found in remission phase indicating a persistent immune reaction and presence of non-eliminated pathogenic factors.