Nicorandil-induced severe oral ulceration.

Nicorandil has been shown to precipitate persistent ulcerative stomatitis in a small percentage of patients. To date over 50 cases have been reported, initially in France and, more recently, in the United Kingdom and Portugal, but this is the first report of nicorandil-induced ulceration in Irish medical or dental literature. It has been suggested that a previous history of aphthous ulceration may predispose the development of nicorandil-induced ulcers, although onlyone of these patients reported a history of recurrent oral ulceration (ROU).