Sweet Syndrome in a Patient With Acute Myeloid Leukemia: A Diagnostic Challenge in the Setting of Chemotherapy-Induced Neutropenia.

A 69-year-old male with acute myeloid leukemia (AML) undergoing chemotherapy developed erythematous skin lesions at sites of prior intravenous access, along with fever and elevated inflammatory markers. Initially suspected of having resistant cellulitis or disseminated infection, his condition did not improve despite broad-spectrum antibiotics. Skin biopsy confirmed Sweet syndrome, and the patient showed rapid clinical improvement following corticosteroid therapy, with resolution of fever and skin lesions within 72 hours. This case underscores the importance of considering Sweet syndrome in neutropenic patients with unexplained fever and skin lesions, as early recognition and treatment can prevent unnecessary antibiotic use and ensure timely continuation of chemotherapy.