Frontiers in endocrinology · 2026
Incidence and risk factors of post-transplant diabetes mellitus after kidney transplantation: a systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Chen Ni, Chen Yuli, Liu Qiuhong, Shu Ying
Аннотация
OBJECTIVE: In order to investigate the incidence rate of post-transplant diabetes mellitus (PTDM) patients and identify the risk factors, we conducted a systematic review of studies published after 2014.
DATA SOURCES: PubMed, EMBASE, Cochrane Library, as well as Web of Science were comprehensively retrieved until June 24, 2024.
SELECTION OF STUDIES: Extracted data via EndNote reference management software and evaluated the risk of bias through the Newcastle-Ottawa Scale (NOS).
DATA EXTRACTION: Statistical analyses were enabled by STATA 15. Heterogeneity was evaluated through the Q test 、the I² statistic sensitivity and subgroup analyses.
DATA SUMMARY: 26 studies from 15 countries involving 8, 727 participants were encompassed. The overall incidence of PTDM was 20%. Meta-analysis revealed that advanced age (>50), hepatitis C virus (HCV) infection, polycystic kidney disease, high body mass index (BMI), high fasting plasma glucose (FPG), hypertriglyceridemia, as well as hypercholesterolemia were significantly related to elevated risk of PTDM (P < 0.05). Meta-analysis of case-control studies further confirmed that advanced age (OR = 1.07, 95% CI: 1.04-1.09), high BMI (OR = 1.23, 95% CI: 1.08-1.39), and hypertriglyceridemia (OR = 1.01, 95% CI: 1.00-1.02) were significant risk factors. Cohort studies additionally identified advanced age, high BMI, high FPG, family history of diabetes, hypertriglyceridemia, and HCV infection as significant risk factors.
CONCLUSIONS: The incidence of PTDM after kidney transplantation is approximately 20%. Advanced age, high BMI, family history of diabetes, high FPG, hypertriglyceridemia, and HCV infection are significant risk factors. Among these, BMI, glucose, lipid abnormalities, and HCV infection are modifiable.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD42024585070.
DATA SOURCES: PubMed, EMBASE, Cochrane Library, as well as Web of Science were comprehensively retrieved until June 24, 2024.
SELECTION OF STUDIES: Extracted data via EndNote reference management software and evaluated the risk of bias through the Newcastle-Ottawa Scale (NOS).
DATA EXTRACTION: Statistical analyses were enabled by STATA 15. Heterogeneity was evaluated through the Q test 、the I² statistic sensitivity and subgroup analyses.
DATA SUMMARY: 26 studies from 15 countries involving 8, 727 participants were encompassed. The overall incidence of PTDM was 20%. Meta-analysis revealed that advanced age (>50), hepatitis C virus (HCV) infection, polycystic kidney disease, high body mass index (BMI), high fasting plasma glucose (FPG), hypertriglyceridemia, as well as hypercholesterolemia were significantly related to elevated risk of PTDM (P < 0.05). Meta-analysis of case-control studies further confirmed that advanced age (OR = 1.07, 95% CI: 1.04-1.09), high BMI (OR = 1.23, 95% CI: 1.08-1.39), and hypertriglyceridemia (OR = 1.01, 95% CI: 1.00-1.02) were significant risk factors. Cohort studies additionally identified advanced age, high BMI, high FPG, family history of diabetes, hypertriglyceridemia, and HCV infection as significant risk factors.
CONCLUSIONS: The incidence of PTDM after kidney transplantation is approximately 20%. Advanced age, high BMI, family history of diabetes, high FPG, hypertriglyceridemia, and HCV infection are significant risk factors. Among these, BMI, glucose, lipid abnormalities, and HCV infection are modifiable.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD42024585070.