Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kapustin Daniel, Zarei Shadi, Wang Wei, Binns Malcolm A, McLaughlin Paula M, Abrahao Agessandro, Black Sandra E, Borrie Michael, Breen David, Casaubon Leanna, Dowlatshahi Dar, Finger Elizabeth, Fischer Corinne E, Frank Andrew, Freedman Morris, Grimes David, Hassan Ayman, Jog Mandar, Kwan Donna, Lang Anthony, Levine Brian, Mandzia Jennifer, Marras Connie, Masellis Mario, Orange Joseph B, Pasternak Stephen, Peltsch Alicia, Pollock Bruce G, Rajji Tarek K, Roberts Angela, Sahlas Demetrios, Saposnik Gustavo, Seitz Dallas, Shoesmith Christen, Southwell Alisia, Steeves Thomas D L, Sunderland Kelly, Swartz Richard H, Tan Brian, Tang-Wai David F, Tartaglia Maria Carmela, Troyer Angela, Turnbull John, Zinman Lorne, ONDRI investigators, Kumar Sanjeev
Аннотация
METHODS: We obtained data from Ontario Neurodegenerative Disease Research Initiative (ONDRI) that included following cohorts: AD (N = 111), CVD (N = 148), PD (N = 136), FTD (N = 50) and ALS (N = 36). We compared the frequency and severity of individual NPS (assessed by the neuropsychiatric inventory questionnaire) across cohorts using generalized estimating equations and analysis of variance. Second, we assessed the relationship of NPS burden with instrumental (iADLs) and basic (ADLs) activities of living across cohorts using multivariate linear regression while adjusting for relevant demographic and clinical covariates.
RESULTS: Frequency of NPS varied across cohorts (χ2(4) = 34.4, p < .001), with post-hoc tests showing that FTD had the greatest frequency as compared to all other cohorts. The FTD cohort also had the greatest severity of NPS (H(4) = 34.5, p < .001). Further, there were differences among cohorts in terms of the association between NPS burden and ADLs (F(4,461) = 3.1, p = 0.02). Post-hoc comparisons suggested that this finding was driven by the FTD group, however, the differences did not remain significant following Bonferroni correction. There were no differences among cohorts in terms of the association between NPS burden and IADLs.
CONCLUSIONS: NPS frequency and severity are markedly greater in FTD as compared to other neurodegenerative diseases. Further, NPS burden appears to be associated differently with function across neurodegenerative disorders, highlighting the need for individualized clinical interventions.