Advances in skin & wound care · 2006
MMP-2 assessment as an indicator of wound healing: A feasibility study.
Клинический случайКлиническое исследование II фазыСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Karim Refaat B, Brito Beatriz L R, Dutrieux Richard P, Lassance Fernanda P, Hage J Joris
Аннотация
OBJECTIVE: Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing.
METHODS: Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface area, > or = 1 cm). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing.
RESULTS: Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing.
CONCLUSION: MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment.
METHODS: Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface area, > or = 1 cm). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing.
RESULTS: Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing.
CONCLUSION: MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment.