Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies.
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Leung Yvonne, Barzilai Nir, Batko-Szwaczka Agnieszka, Beker Nina, Boerner Kathrin, Brayne Carol, Brodaty Henry, Cheung Karen Siu-Lan, Corrada María M, Crawford John D, Galbussera Alessia A, Gondo Yasuyuki, Holstege Henne, Hulsman Marc, Ishioka Yoshiko Lily, Jopp Daniela, Kawas Claudia H, Kaye Jeff, Kochan Nicole A, Lau Bobo Hi-Po, Lipnicki Darren M, Lo Jessica W, Lucca Ugo, Makkar Steve R, Marcon Gabriella, Martin Peter, Meguro Kenichi, Milman Sofiya, Poon Leonard W, Recchia Angela, Ribeiro Oscar, Riva Emma, Rott Christoph, Sikkes Sietske Am, Skoog Ingmar, Stephan Blossom, Szewieczek Jan, Teixeira Laetitia, Tettamanti Mauro, Wilczyński Krzysztof, Sachdev Perminder
Аннотация
METHODS: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed.
RESULTS: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92-0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35-0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI).
DISCUSSION: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.