Decline in Isotope Dilution Space Ratio Above Age 60 Could Affect Energy Estimates Using the Doubly Labeled Water Method.
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Wong William W, Speakman John R, Ainslie Philip N, Anderson Liam J, Arab Leonore, Baddou Issad, Bedu-Addo Kweku, Blaak Ellen E, Blanc Stephane, Bonomi Alberto G, Bouten Carlijn Vc, Bovet Pascal, Buchowski Maciej S, Butte Nancy F, Camps Stefan G, Casper Regina, Close Graeme L, Colbert Lisa H, Cooper Jamie A, Das Sai K, Davies Peter Sw, Eaton Simon, Ekelund Ulf, Hambly Catherine, El Hamdouchi Asmaa, Entringer Sonja, Fudge Barry W, Gillingham Melanie, Goris Annelies H, Gurven Micheal, Hoos Marije B, Hu Sumei, Joosen Annemiek, Katzmarzyk Peter T, Kempen Kitty P, Kimura Misaka, Kraus William E, Kushner Robert F, Larsson Christel L, Morehen James C, Morton James P, Neuhouser Marian L, Nicklas Theresa A, Ojiambo Robert M, Pietilainen Kirsi H, Pitsiladis Yannis P, Plasqui Guy, Prentice Ross L, Rabinovich Roberto, Racette Susan B, Raichen David A, Redman Leanne, Ravussin Eric, Reilly John J, Roberts Susan, Scuitt Albertine J, Sjödin Anders M, Stice Eric, Urlacher Samuel S, Valenti Giulio, van Etten Ludo M, Van Mil Edgar A, Verbunt Jeanine A, Wells Jonathan Ck, Wilson George, Yoshida Tsukasa, Zhang Xueying, Loechl Cornelia U, Luke Amy, Murphy-Alford Alexia J, Pontzer Herman, Sagayama Hiroyuki, Rood Jennifer C, Schoeller Dale A, Westerterp Klaas R, Yamada Yosuke, IAEA DLW Database Consortium
Аннотация
OBJECTIVES: We evaluated the potential associations of age, sex, ethnicity, anthropometry, body composition, turnover rates of the isotopes, and geographical elevation with DSR.
METHODS: We used univariate regression analysis to explore the relationships between the continuous variables and analysis of variance to test the relationships between the categorical variables with DSR. Subsequently, we used general linear model (GLM) and 1-way analysis of variance to evaluate the simultaneous associations of age, sex, ethnicity, fat-free mass (FFM) and fat mass (FM) on DSR.
RESULTS: From 5678 measurements complied from studies around the world with diverse ethnicity and living at various elevations, the mean DSR was 1.0364 ± 0.0141. No meaningful physiologic effect of any of the continuous and categorical variable on DSR was detected. General linear model analysis revealed no effect of FFM and FM (P > 0.33) on DSR, but DSR decreased with age (P < 0.001) among those aged 60 y and older regardless of sex. Among the Whites who were younger than 60 y, DSR was not related to FFM and FM (P = 0.73) but was affected by both age and sex (P < 0.001).
CONCLUSIONS: Previous estimates of age-related decline in TEE may have overestimated TEE at age 90 y. Validation studies on older participants are required to confirm this finding.