RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 1997
[31P-MR spectroscopy of the human liver--the spectral indications of lymphoma infiltration].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Heindel W, du Mesnil de Rochemont R, Kugel H, Ernst S, Tesch H, Diehl V, Lackner K
Аннотация
PURPOSE: To evaluate whether phosphorus magnetic resonance spectroscopy (31P-MRS) enables a non-invasive detection of liver involvement in systemic diseases like Hodgkin's lymphoma.
MATERIALS AND METHODS: Using a clinical 1.5 Tesla whole-body MR system image-guided localised phosphorus MR spectra from the anatomically defined volumes of interests were measured. A combination of surface coil, adiabatic excitation pulse and modified image-selected in vivo spectroscopy (ISIS)-sequence was applied. The spectroscopy data were evaluated quantitatively with a time-domain fit programme using non-linear optimisation algorithms to quantify peak areas. After establishment of the examination protocol, 22 healthy volunteers and 13 patients with suspected lymphoma infiltration of the liver were examined.
RESULTS: Liver spectra of patients suffering from lymphoma infiltration differed significantly from spectra of persons with normal liver: 1. The peak area ratio of phosphomonoesters (PME) to beta-NTP was elevated in all patients with histologically confirmed liver lymphoma. 2. Patients suffering from Hodgkin's disease with specific or unspecific liver infiltration (n = 7) could be differentiated from patients without liver involvement. In case of infiltrated liver, the peak area ratio PME to beta-NTP was increased, and the pH value was shifted to lower values. Unambiguous differentiation between non-specific (n = 3) and specific (n = 4) infiltration of the liver was not possible. 3. In patients after cytostatic treatment (n = 3), an increase of the peak area ratio of inorganic phosphate to beta-NTP was observed.
CONCLUSIONS: Our preliminary results indicate that 31P-MRS can yield pointers to liver involvement in patients with systemic diseases such as Hodgkin's disease, which may be hardly detected by imaging methods.
MATERIALS AND METHODS: Using a clinical 1.5 Tesla whole-body MR system image-guided localised phosphorus MR spectra from the anatomically defined volumes of interests were measured. A combination of surface coil, adiabatic excitation pulse and modified image-selected in vivo spectroscopy (ISIS)-sequence was applied. The spectroscopy data were evaluated quantitatively with a time-domain fit programme using non-linear optimisation algorithms to quantify peak areas. After establishment of the examination protocol, 22 healthy volunteers and 13 patients with suspected lymphoma infiltration of the liver were examined.
RESULTS: Liver spectra of patients suffering from lymphoma infiltration differed significantly from spectra of persons with normal liver: 1. The peak area ratio of phosphomonoesters (PME) to beta-NTP was elevated in all patients with histologically confirmed liver lymphoma. 2. Patients suffering from Hodgkin's disease with specific or unspecific liver infiltration (n = 7) could be differentiated from patients without liver involvement. In case of infiltrated liver, the peak area ratio PME to beta-NTP was increased, and the pH value was shifted to lower values. Unambiguous differentiation between non-specific (n = 3) and specific (n = 4) infiltration of the liver was not possible. 3. In patients after cytostatic treatment (n = 3), an increase of the peak area ratio of inorganic phosphate to beta-NTP was observed.
CONCLUSIONS: Our preliminary results indicate that 31P-MRS can yield pointers to liver involvement in patients with systemic diseases such as Hodgkin's disease, which may be hardly detected by imaging methods.