Terapevticheskii arkhiv · 2000
[Chronic hepatitis: indicators of disease activity].
Сравнительное исследованиеАннотация на английскомСтатьяНазвание и аннотация: Оригинал на русском
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Masevich Ts G, Ermolaeva L G
Аннотация
AIM: To assess correlations between activity of chronic hepatitis (CH) by morphological data on the liver and alaninaminotransferase (AlAT) serum levels in patients with viral and alcoholic liver lesions.
MATERIALS AND METHODS: Serological, biochemical blood tests and histology of hepatic biopsy were made in 47 patients with chronic hepatitis.
RESULTS: The Knodell index characterizing the activity of chronic hepatitis by morphological evidence correlated with AlAT activity in the serum. Normal values may be associated with 1 to 5 scores by the Knodell index. AsAT/AlAT was higher in patients with CH free of virus markers.
CONCLUSION: Morphological data (Knodell's index), AlAT activity and AsAT/AlAT indicate CH activity. AsAT/AlAT may help in elucidation of the presence or absence of alcohol abuse.
MATERIALS AND METHODS: Serological, biochemical blood tests and histology of hepatic biopsy were made in 47 patients with chronic hepatitis.
RESULTS: The Knodell index characterizing the activity of chronic hepatitis by morphological evidence correlated with AlAT activity in the serum. Normal values may be associated with 1 to 5 scores by the Knodell index. AsAT/AlAT was higher in patients with CH free of virus markers.
CONCLUSION: Morphological data (Knodell's index), AlAT activity and AsAT/AlAT indicate CH activity. AsAT/AlAT may help in elucidation of the presence or absence of alcohol abuse.