Dermatology (Basel, Switzerland) · 2015
The effect of isotretinoin on retinol-binding protein 4, leptin, adiponectin and insulin resistance in acne vulgaris patients.
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Karadag Ayse Serap, Ertugrul Derun Taner, Takci Zennure, Bilgili Serap Gunes, Namuslu Mehmet, Ata Naim, Sekeroglu Ramazan
Аннотация
BACKGROUND: The effect of isotretinoin (ISO) on adipokines and insulin resistance has been investigated in a few studies, and the results are conflicting.
OBJECTIVE: The aim of this study was to investigate the effect of ISO treatment on insulin resistance and adipokines.
METHODS: Thirty-three patients with acne vulgaris and a control group of 30 healthy volunteers were included in our study. Screening for the biochemical parameters was performed just before the initiation and after 3 months of ISO treatment.
RESULTS: In the acne group, basal leptin levels were significantly lower (p = 0.003) and basal adiponectin levels significantly higher (p = 0.008) compared with the control group. After ISO treatment, leptin levels (p = 0.0005) decreased and adiponectin levels (p = 0.003) increased significantly. However, measurements of fasting blood glucose, insulin, C peptide, retinol-binding protein 4 (RBP4), homeostasis model assessment insulin resistance and BMI did not differ after ISO treatment.
CONCLUSION: ISO may affect leptin and adiponectin levels. It does not, however, affect insulin resistance and RBP4 levels.
OBJECTIVE: The aim of this study was to investigate the effect of ISO treatment on insulin resistance and adipokines.
METHODS: Thirty-three patients with acne vulgaris and a control group of 30 healthy volunteers were included in our study. Screening for the biochemical parameters was performed just before the initiation and after 3 months of ISO treatment.
RESULTS: In the acne group, basal leptin levels were significantly lower (p = 0.003) and basal adiponectin levels significantly higher (p = 0.008) compared with the control group. After ISO treatment, leptin levels (p = 0.0005) decreased and adiponectin levels (p = 0.003) increased significantly. However, measurements of fasting blood glucose, insulin, C peptide, retinol-binding protein 4 (RBP4), homeostasis model assessment insulin resistance and BMI did not differ after ISO treatment.
CONCLUSION: ISO may affect leptin and adiponectin levels. It does not, however, affect insulin resistance and RBP4 levels.