Cellular oncology (Dordrecht, Netherlands) · 2025
Multi-omics analysis delineates molecular signatures of spinal ependymal tumor.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Liu Weihao, Ning Chao, Geng Xiaohan, Wang Bo, Zhang Yaowu, Wang Chong, Liu Yixiang, Zheng Guanghao, Wang Yongzhi, Wang Xinyu, Li Dong, Jia Wenqing
Аннотация
BACKGROUND: Spinal ependymal tumors are a diverse group of neoplasms encompassing four subtypes: spinal ependymoma (SP-EPN), spinal ependymoma, MYCN-amplification (SP-EPN-MYCN), spinal myxopapillary ependymoma (SP-MPE), and spinal subependymoma (SP-SE). However, the molecular differences among these subtypes remain largely unknown.
METHODS: Using an integrated multi-omics approach (whole-genome sequencing, RNA-seq, and mass spectrometry), we identified the distinct molecular characteristics of three subtypes except for SP-EPN-MYCN.
RESULTS: In SP-EPN, abnormal enrichment of ciliary signaling, particularly involving the MKS complex, was evident. SP-MPE exhibited significant dysregulation of mitochondrial metabolism, reflecting a metabolic profile aligned with the Warburg effect. SP-SE tumors showed enhanced activity of immune-related pathways, including interferon signaling and extracellular vesicle dynamics, suggesting a distinct tumor microenvironment.
CONCLUSION: This pilot study identifies candidate molecular markers in a single-center spinal ependymal tumor cohort.
CLINICAL TRIAL NUMBER: Not applicable.
METHODS: Using an integrated multi-omics approach (whole-genome sequencing, RNA-seq, and mass spectrometry), we identified the distinct molecular characteristics of three subtypes except for SP-EPN-MYCN.
RESULTS: In SP-EPN, abnormal enrichment of ciliary signaling, particularly involving the MKS complex, was evident. SP-MPE exhibited significant dysregulation of mitochondrial metabolism, reflecting a metabolic profile aligned with the Warburg effect. SP-SE tumors showed enhanced activity of immune-related pathways, including interferon signaling and extracellular vesicle dynamics, suggesting a distinct tumor microenvironment.
CONCLUSION: This pilot study identifies candidate molecular markers in a single-center spinal ependymal tumor cohort.
CLINICAL TRIAL NUMBER: Not applicable.