Journal of biomedical optics · 2024
Evaluating hemodynamic response to treatment in patients with peripheral arterial disease using dynamic vascular optical spectroscopy.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Maheshwari Nisha, Marone Alessandro, Kim Stephen H K, Bajakian Danielle R, Hielscher Andreas H
Аннотация
SIGNIFICANCE: Tracking changes in the vasculature of patients with peripheral arterial disease (PAD) may identify the need for follow-up treatment within only weeks after an initial intervention, enabling timely support and improving patient outcomes.
AIM: We aim to evaluate dynamic vascular optical spectroscopy's (DVOS's) ability to accurately monitor the hemodynamics of affected arteries in patients with PAD after a surgical intervention and predict long-term clinical outcomes.
APPROACH: A DVOS system non-invasively monitored the blood flow through 256 lower extremity arteries in 80 PAD patients immediately before, immediately after, and 3 to 4 weeks after they underwent a surgical intervention.
RESULTS: Hemodynamic changes measured by DVOS after a revascularization procedure (RP) classified patient long-term ( 6.2 ± 4.4 months) outcomes with high accuracy [81.6% for patients with ulcers ( n = 31 ); 81.1% for patients without ulcers ( n = 54 )] by 3 to 4 weeks after the RP, outperforming available ankle-brachial index and ultrasound measurements. In addition, DVOS parameters distinguished between patients who underwent only a catheter angiography (CA) and patients who underwent both a CA and RP ( P < 0.05 ).
CONCLUSIONS: The DVOS system was able to classify patient long-term clinical outcomes with high accuracy within one month after an RP and distinguish among different interventions. DVOS may be a promising alternative or adjunct to existing monitoring approaches.
AIM: We aim to evaluate dynamic vascular optical spectroscopy's (DVOS's) ability to accurately monitor the hemodynamics of affected arteries in patients with PAD after a surgical intervention and predict long-term clinical outcomes.
APPROACH: A DVOS system non-invasively monitored the blood flow through 256 lower extremity arteries in 80 PAD patients immediately before, immediately after, and 3 to 4 weeks after they underwent a surgical intervention.
RESULTS: Hemodynamic changes measured by DVOS after a revascularization procedure (RP) classified patient long-term ( 6.2 ± 4.4 months) outcomes with high accuracy [81.6% for patients with ulcers ( n = 31 ); 81.1% for patients without ulcers ( n = 54 )] by 3 to 4 weeks after the RP, outperforming available ankle-brachial index and ultrasound measurements. In addition, DVOS parameters distinguished between patients who underwent only a catheter angiography (CA) and patients who underwent both a CA and RP ( P < 0.05 ).
CONCLUSIONS: The DVOS system was able to classify patient long-term clinical outcomes with high accuracy within one month after an RP and distinguish among different interventions. DVOS may be a promising alternative or adjunct to existing monitoring approaches.