Usability of Levodopa Cyclops® Compared to INBRIJA® During an off Episode in Parkinson's Disease Patients.

BACKGROUND

This study compares the usability of two levodopa dry powder inhalers. The Inbrija® inhaler involves several preparatory steps, including blister opening and capsule insertion. The Cyclops® inhaler is preloaded and disposable, designed for immediate use. Ease of use is critical, as cognitive and motor impairments may hinder the patients' ability to operate an inhaler.

METHODS

Sixteen patients with Parkinson's disease experiencing predictable and recognizable off episodes were enrolled. After receiving inhalation instructions, patients performed the inhalation maneuver during their off-episode to assess the correct execution. They completed a questionnaire evaluating the ease of use for both devices. Each patient used both the Cyclops® and Inbrija® inhalers in a randomized sequence and completed the questionnaire.

RESULTS

All 16 patients correctly performed the Cyclops® inhaler steps during an off episode, while only 10 patients successfully completed the steps with the Inbrija® inhaler. Twelve of the sixteen patients (75%) expressed a preference for the Cyclops®, rating it higher in terms of ease of use and hygiene. However, concerns were raised regarding the environmental sustainability of its single-use design. For the Inbrija®, patients reported difficulties with opening the peel-off blister packaging, assembling the mouthpiece, and puncturing the capsules.

CONCLUSION

The Cyclops® inhaler was more user-friendly during off episodes due to its ease of use and simpler handling. Since the Cyclops® is preloaded, it requires fewer and simpler steps. The preparation steps of Inbrija® posed usability challenges, particularly with opening the peel-off blister packaging of the capsule and assembling the mouthpiece and handle.