Journal of International Society of Preventive & Community Dentistry · 2026
A Comparative Evaluation of Serum and Salivary Antioxidant Levels in Healthy Controls, Gingivitis, and Periodontitis Patients.
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Dsouza Teena Sheethal, Ashwini Konchady, Roopashree Padmanabha Poojary, Acharya Ranjitha
Аннотация
OBJECTIVE: Periodontitis is a chronic inflammatory disorder that gives rise to tissue damage and loss due to the complex interaction between pathogenic bacteria and the host's immune response. The aim of this study is to determine the lipid peroxidation, total antioxidant (AO) capacity (TAC), and superoxide dismutase (SOD) levels in patients diagnosed with chronic gingivitis and chronic periodontitis and in periodontally healthy control subjects.
METHODS: The subjects were divided into three groups. Blood sample and saliva were collected. TAC, MDA, and SOD levels were estimated by spectrophotometric methods. SOD in the saliva samples was analyzed by using the enzyme-linked immunosorbent assay (ELISA) kit method.
RESULTS: The mean age of the study population in the control group was 45.21 ± 13.12, which in the gingivitis group was 44.12 ± 9.10 and in the periodontitis group was 42.19 ± 12.11. TAC and SOD levels were significantly reduced in both serum and saliva in the periodontitis compared to control and the gingivitis group. MDA levels were significantly increased in the serum and the saliva of the periodontitis compared to control and the gingivitis group.
CONCLUSION: Oxidative stress, or the imbalance between oxidants and AO, is a major factor in the development and course of periodontitis.
METHODS: The subjects were divided into three groups. Blood sample and saliva were collected. TAC, MDA, and SOD levels were estimated by spectrophotometric methods. SOD in the saliva samples was analyzed by using the enzyme-linked immunosorbent assay (ELISA) kit method.
RESULTS: The mean age of the study population in the control group was 45.21 ± 13.12, which in the gingivitis group was 44.12 ± 9.10 and in the periodontitis group was 42.19 ± 12.11. TAC and SOD levels were significantly reduced in both serum and saliva in the periodontitis compared to control and the gingivitis group. MDA levels were significantly increased in the serum and the saliva of the periodontitis compared to control and the gingivitis group.
CONCLUSION: Oxidative stress, or the imbalance between oxidants and AO, is a major factor in the development and course of periodontitis.