Dementia and geriatric cognitive disorders · 2011
Association of clusterin gene polymorphisms with late-onset Alzheimer's disease.
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Gu Huiying, Wei Xing, Chen Shirley, Kurz Alexander, Müller Ulrich, Gasser Thomas, Dodel Richard C, Farlow Martin R, Du Yansheng
Аннотация
BACKGROUND/AIMS: Some studies have implicated the role of apolipoprotein J [clusterin (CLU), apoJ] in the pathogenesis of Alzheimer's disease (AD). In this study, we investigated the polymorphisms rs11136000 and rs9331888 within CLU in late-onset sporadic AD (LOAD) patients and nondemented subjects.
METHODS: LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion.
RESULTS: Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk.
CONCLUSION: The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.
METHODS: LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion.
RESULTS: Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk.
CONCLUSION: The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.