Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2014
Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Hoppe Steffi, von Loeffelholz Christian, Lock Johan F, Doecke Stephanie, Sinn Bruno V, Rieger Anja, Malinowski Maciej, Pfeiffer Andreas F H, Neuhaus Peter, Stockmann Martin
Аннотация
BACKGROUND: The impact of nonalcoholic fatty liver disease (NAFLD) comprising simple steatosis (NAFL) and steatohepatitis (NASH) on liver recovery after partial hepatectomy has not been evaluated. This pilot study investigated whether there is an effect of proven NAFLD on liver recovery.
METHODS: Thirty-one patients elected for partial hepatectomy were characterized and included into a prospective study. Liver samples were staged according to the NAFLD activity score. Liver function was measured by using the LiMAx method on postoperative days (POD) 1, 3, 5, and 10.
RESULTS: Nineteen patients were identified to suffer from NAFLD (NAFL, n = 11; NASH, n = 8). In NAFL, preoperative liver function (p = .48) and hepatic recovery on POD 1, 3, and 5 was comparable to controls (p > .05, respectively), while it was impaired on POD 10 (p = .022). NASH patients had preoperative enzymatic function comparable to controls (p = .10), but there was a trend to reduced levels on POD 1 (p = .082) and 5 (p = .062), which became significant on POD 10 (p = .003).
CONCLUSION: This study suggests that NAFLD impairs functional recovery assessed by LiMAx after partial hepatectomy.
METHODS: Thirty-one patients elected for partial hepatectomy were characterized and included into a prospective study. Liver samples were staged according to the NAFLD activity score. Liver function was measured by using the LiMAx method on postoperative days (POD) 1, 3, 5, and 10.
RESULTS: Nineteen patients were identified to suffer from NAFLD (NAFL, n = 11; NASH, n = 8). In NAFL, preoperative liver function (p = .48) and hepatic recovery on POD 1, 3, and 5 was comparable to controls (p > .05, respectively), while it was impaired on POD 10 (p = .022). NASH patients had preoperative enzymatic function comparable to controls (p = .10), but there was a trend to reduced levels on POD 1 (p = .082) and 5 (p = .062), which became significant on POD 10 (p = .003).
CONCLUSION: This study suggests that NAFLD impairs functional recovery assessed by LiMAx after partial hepatectomy.
Предметные рубрики MeSH
AdenocarcinomaAdultAgedAnthropometryCarcinoma, HepatocellularCholangiocarcinomaColorectal NeoplasmsFatty LiverFemaleFollow-Up StudiesHepatectomyHumansLength of StayLiver Function TestsLiver NeoplasmsLiver RegenerationMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseObesityPilot ProjectsPostoperative PeriodProspective StudiesRecovery of FunctionSeverity of Illness IndexSingle-Blind Method