Infection · 2019
Simultaneous colonization by Escherichia coli and Klebsiella pneumoniae harboring mcr-1 in Brazil.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Perdigão Neto Lauro Vieira, Corscadden Louise, Martins Roberta Cristina Ruedas, Nagano Débora Satie, Cunha Marcos Paulo Vieira, Neves Patrícia Regina, Franco Lucas Augusto Moyses, Moura Maria Luísa Nascimento, Rizek Camila Fonseca, Guimarães Thais, Boszczowski Ícaro, Rossi Flávia, Levin Anna S, Stabler Richard A, Costa Silvia F
Аннотация
CASE PRESENTATION: We present a case report of a woman, concurrently colonized by polymyxin-resistant E. coli and K. pneumoniae. A Brazilian female patient, in her mid-fifties, was hospitalized with schistosomiasis. During hospitalization, polymyxin-resistant E. coli and K. pneumoniae were isolated from surveillance cultures.
METHODS: Identification, antimicrobial susceptibility testings, PCR for mcr-1, plasmid transfer by conjugation and whole genome sequencing were performed.
RESULTS: E. coli ST744 and K. pneumoniae ST101 carrying mcr-1 gene were described. Transconjugant E. coli was positive for mcr-1 and IncX4 by PCR. The plasmid is a 33,304-base pair plasmid, and the mcr-1 gene was the only antimicrobial resistance gene present in the plasmid.
CONCLUSIONS: This study presents a case report of a hospitalized woman, concurrently colonized by mcr-1-harboring E. coli ST744, a different ST from previously described in Brazil, and a K. pneumoniae ST101.
METHODS: Identification, antimicrobial susceptibility testings, PCR for mcr-1, plasmid transfer by conjugation and whole genome sequencing were performed.
RESULTS: E. coli ST744 and K. pneumoniae ST101 carrying mcr-1 gene were described. Transconjugant E. coli was positive for mcr-1 and IncX4 by PCR. The plasmid is a 33,304-base pair plasmid, and the mcr-1 gene was the only antimicrobial resistance gene present in the plasmid.
CONCLUSIONS: This study presents a case report of a hospitalized woman, concurrently colonized by mcr-1-harboring E. coli ST744, a different ST from previously described in Brazil, and a K. pneumoniae ST101.