NEUROPSYCHIATRIC AND PSYCHOGENETIC ASPECTS OF POST-TRAUMATIC STRESS DISORDERS ASSOCIATED WITH THE CHORNOBYL DISASTER AND THE RUSSIAN-UKRAINIAN WAR: FOCUS ON THE ENDOCANABINOID SYSTEM.

This review article is devoted to neuropsychiatric and psychogenetic aspects of posttraumatic stress disorder(PTSD) in the context of traumatic scenarios of the Chornobyl disaster and the RussianUkrainian war.Unprecedented challenges associated with manmade, sociopolitical, and military emergencies contribute to the significant spread of mental disorders among the military and civilian populations of Ukraine. Combined with significant difficulties in treatment and the limited effectiveness of existing treatment strategies, there is a serious clinical gap in the diagnosis and management of PTSD. Therefore, research into the genetic and epigenetic markers of this disorder, the creation and implementation of PTSD prevention models, followed by the development of individualized therapeutic and rehabilitation strategies aimed at reducing the duration of treatment, improving its effectiveness, and facilitating patient adaptation in society, remains an extremely relevant problem in clinical neuroscience. Particular attention is paid to the endocannabinoid system as a potential target for therapeutic intervention in PTSD, promising research directions, and the possibilities for the therapeutic use of cannabinoids in clinical practice.