The journal of prevention of Alzheimer's disease · 2026
Healthy lifestyle and Alzheimer's disease in individuals with hyperlipidemia: A prospective cohort study.
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Sun Danyang, Yu Linling, Liao Chenqi, Xu Yuzhong, Liu Wei, Wang Xiong
Аннотация
BACKGROUND: Whether healthy lifestyle behaviors are associated with Alzheimer's disease (AD) risk among individuals with hyperlipidemia remains unclear.
METHODS: We analyzed 241,642 dementia-free participants from the UK Biobank. A weighted lifestyle score (0-7) was derived from seven factors and categorized into five tiers. Hyperlipidemia was defined as lipid-lowering medication use or LDL-cholesterol ≥ 4.0 mmol/L. Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS: Over a median follow-up of 14.5 years, 1728 AD cases occurred, including 977 cases among 104,082 individuals with hyperlipidemia. Compared with the intermediate tier, unhealthy lifestyle was associated with elevated AD risk (HR: 1.17; 95% CI: 1.02-1.35), while healtshy and very healthy tiers were associated with progressively lower risk (HR=0.85 and 0.74, respectively). These associations were evident among individuals with hyperlipidemia, but not statistically significant among those without hyperlipidemia.
CONCLUSIONS: Healthy lifestyle patterns were associated with lower AD risk among individuals with hyperlipidemia, with greater risk reductions observed for healthier lifestyle tiers.
METHODS: We analyzed 241,642 dementia-free participants from the UK Biobank. A weighted lifestyle score (0-7) was derived from seven factors and categorized into five tiers. Hyperlipidemia was defined as lipid-lowering medication use or LDL-cholesterol ≥ 4.0 mmol/L. Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS: Over a median follow-up of 14.5 years, 1728 AD cases occurred, including 977 cases among 104,082 individuals with hyperlipidemia. Compared with the intermediate tier, unhealthy lifestyle was associated with elevated AD risk (HR: 1.17; 95% CI: 1.02-1.35), while healtshy and very healthy tiers were associated with progressively lower risk (HR=0.85 and 0.74, respectively). These associations were evident among individuals with hyperlipidemia, but not statistically significant among those without hyperlipidemia.
CONCLUSIONS: Healthy lifestyle patterns were associated with lower AD risk among individuals with hyperlipidemia, with greater risk reductions observed for healthier lifestyle tiers.