Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population.
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Willett Julian Daniel Sunday, Waqas Mohamad, Naumenko Serhiy, Mullin Kristina, Hecker Julian, Bertram Lars, Lange Christoph, Vlachos Ioannis, Hide Winston, Tanzi Rudolph E, Prokopenko Dmitry
Аннотация
INTRODUCTION: Alzheimer's disease (AD) is the most common form of dementia. Studies have suggested prevalence is greater in individuals self-identifying as Hispanic. Population-specific results enable personalized and equitable interventions. Ethnicity as a stratifier co-occurs with genomic inflation due to heterogeneity.
METHODS: We conducted genome-wide association studies (GWAS) and meta-analyses among subjects from the Alzheimer's Disease Sequencing Project (ADSP) Umbrella whole genome sequencing (WGS) dataset who self-identified as Hispanic and All of Us (AoU) sub-cohorts matched to that cohort, using projected genetically-derived principal components.
RESULTS: We identified a common variant in PIEZO2 on chromosome 18 protective for AD in ADSP subjects, with a p-value just beyond genome-wide significance (p = 5.4 × 10 - 8 $5.4\ \times {{10}^{ - 8}}$ ). Meta-analyses with genetically-matched AoU participants yielded three (two novel) genome-wide significant AD-associated loci based on rare lead variants: rs374043832 (RGS6/PSEN1), rs192423465 (ASPSCR1), and rs935208076 (GDAP2), which were nominally significant in AoU sub-cohorts.
DISCUSSION: We demonstrate a way to match subjects between large biobanks and small disease-specific cohorts, enabling novel findings.
METHODS: We conducted genome-wide association studies (GWAS) and meta-analyses among subjects from the Alzheimer's Disease Sequencing Project (ADSP) Umbrella whole genome sequencing (WGS) dataset who self-identified as Hispanic and All of Us (AoU) sub-cohorts matched to that cohort, using projected genetically-derived principal components.
RESULTS: We identified a common variant in PIEZO2 on chromosome 18 protective for AD in ADSP subjects, with a p-value just beyond genome-wide significance (p = 5.4 × 10 - 8 $5.4\ \times {{10}^{ - 8}}$ ). Meta-analyses with genetically-matched AoU participants yielded three (two novel) genome-wide significant AD-associated loci based on rare lead variants: rs374043832 (RGS6/PSEN1), rs192423465 (ASPSCR1), and rs935208076 (GDAP2), which were nominally significant in AoU sub-cohorts.
DISCUSSION: We demonstrate a way to match subjects between large biobanks and small disease-specific cohorts, enabling novel findings.